After a large number of clinical data research shows that HIV antiviral drugs after long-term use, generally do not tend to cause significant toxic side effects. Tenofovir, one of the antiviral drugs, may cause abnormalities in calcium and phosphorus metabolism in the kidneys or damage to the renal tubules in some people who take it for a long time; others, such as Crestor, may cause some abnormalities in lipid metabolism; there are other efavirenz tablets, which may cause some psychiatric symptoms, but usually in the early stage. Most patients are not prone to other toxic side effects after long-term regulated dosing and generally require close monitoring. In addition, lamivudine has no significant toxic side effects and generally requires regular testing of liver and kidney function.