Diabetes mellitus urine protein turn negative is generally not considered cured, need to adhere to long-term standardized treatment. Diabetes mellitus is a common endocrine disease, usually requires long-term glucose control treatment through oral hypoglycemic drugs or insulin. When proteinuria occurs in diabetic patients, it is usually considered as diabetic nephropathy. In stage I diabetic nephropathy, there may be transient micro proteinuria during exercise, stress, and poor glycemic control. Persistent microalbuminuria occurs in stage II. If diabetic patients have developed symptoms of proteinuria, it is usually difficult to be cured, and long-term treatment should be adhered to, including the control of blood glucose, blood pressure, blood lipids, etc., to protect renal function and slow down the progress of the disease. Patients with diabetic urinary protein are advised to seek timely medical attention.