Chronic nephritis blood uric acid 600 μmol / L with febuxostat treatment needs to be based on the patient’s condition, usually there is no fixed time, the patient’s blood uric acid down to the normal range, you can reduce the dosage or stop the drug. Uric acid is the end product of purine metabolism, when chronic nephritis leads to glomerular filtration abnormality, uric acid synthesis or excretion will cause hyperuricemia. Febuxostat is a xanthine oxidase inhibitor, which can inhibit uric acid synthesis. But chronic nephritis blood uric acid 600μmol / L specific need to use the drug for how long need to assess the patient’s blood uric acid level, and actively treat the chronic nephritis primary disease. Febuxostat may occur chest pain, edema, fatigue, gait disturbance, influenza symptoms, pain, thirst and other adverse reactions, while patients undergoing treatment with azathioprine, mercaptopurine is contraindicated. Patients with chronic nephritis with blood uric acid 600μmol/L are advised to go to the regular hospital in time and standardize the treatment under the guidance of the doctor.