Si Reverse San has the function of dispersing heat, dredging the liver and regulating the spleen, and is applicable to fever and syncope with no warmth in the hands and feet, abdominal pain, coercive and rib distension and pain, and is generally not used for the treatment of chest pain. Si Reverse San is composed of Bran-fried Citrus Aurantium Husk, Radix Bupleurum Chinense, Radix Paeoniae Alba and Radix et Rhizoma Glycyrrhizae. The drug has the function of dispelling depressed heat, dredging the liver and regulating the spleen. It is mainly used for treating Yang depression and syncope (poor circulation of Yang qi leading to cold limbs) or liver and spleen disharmony, with symptoms such as lack of warmth in the hands and feet, abdominal pain, distension and pain in the abdomen and ribs, diarrhea and heaviness in the lower body, and stringy pulse. The adverse effects and contraindications of Si Reverse San are not clear. It is necessary to consult a traditional Chinese medicine practitioner for diagnosis before taking Si-Yi San and use it under the guidance of a doctor. If there is any discomfort, please consult a doctor promptly.