Postoperative lower extremity thrombosis with review of D-dimer 0.88mg/L requires oral medication. For patients with lower extremity thrombosis after surgery, review of D-dimer 0.88mg/L should be taken seriously. Under normal circumstances, when D-dimer is less than 0.88mg/L, it usually suggests that there is no need to worry, and when the D-dimer level is greater than 0.88mg/L, it is usually considered to be at increased risk of thrombosis. Patients with a D-dimer level of 0.88mg/L, especially after undergoing lower extremity thrombosis surgery, still suggest the possibility of thrombosis, and therefore must take oral anticoagulant drugs aspirin, clopidogrel bisulfate, and other medications to avoid the occurrence of thrombosis. It is also necessary to closely observe the patient’s condition. When there is swelling, pain in the lower limbs, and a decrease in skin temperature, it is necessary to review the deep vein ultrasound in a timely manner. According to the results of the examination, it is recommended to standardize the use of drugs under the guidance of the doctor to avoid complications.