Treatment for non-small cell lung cancer mainly includes surgery, radiotherapy and chemotherapy, while local treatment is mainly surgery and radiotherapy. The 5-year survival rate of surgical treatment for stage I and II is 50-70%, but only about 30% of patients can be surgically removed at the time of consultation, while the 5-year survival rate of conventional radiotherapy for stage I NSCLC is only 10-30%, and the local control rate is only 50%, and the 1-year local control rate of stage III NSCLC is less than 2%. Some personnel improve the local control rate by increasing the radiation dose, but it cannot be improved due to the dose limitation of the normal tissue around the tumor. The whole-body gamma knife is a stereotactic radiotherapy device developed independently in China, which has the characteristics of high precision, high dose and high efficacy and plays a significant role in the treatment of non-small cell lung cancer. Using whole-body gamma knife treatment, the main reactions of whole-body gamma knife treatment for non-small cell lung cancer include radiation pneumonia and radiation esophagitis, and leukopenia. The whole-body gamma knife technique is to rotate and focus 30 cobalt 60 by means of a rotating cone, so that the tumor is in the focal point and receives a continuous high-dose irradiation, while the surrounding normal tissues receive only a transient scanning low-dose irradiation. The dose intensity gradually decreases from the center of the focal point to the edges. In the treatment of larger tumors, multiple targets are used to fill the tumor. By adjusting the target aperture, number, location and weight, the tumor can be irradiated with a high dose. Another advantage of whole-body gamma knife is that the radiation reflection is lighter. Our original whole-body gamma knife treatment for non-small cell lung cancer is safe, painless and effective. With the passage of time, the whole-body gamma knife will be more and more people recognize and accept.