Extensive stage small cell lung cancer still requires chemotherapy. Small cell lung cancer is a poorly differentiated neuroendocrine tumor with a high degree of malignancy, often found with distant metastases, and surgery is generally not recommended. However, small cell lung cancer is very sensitive to chemotherapy, which is the basic plan of treatment. Chemotherapy drugs mainly include etoposide or irinotecan combined with cisplatin or carboplatin. Patients with extensive stage are mainly treated with chemotherapy-based comprehensive treatment. Patients with extensive stage and brain metastasis, depending on whether the patient has neurological symptoms or not, can be given chemotherapeutic drugs before or after whole brain radiotherapy. If the above situation occurs, please consult a doctor for reasonable and standardized diagnosis and treatment, and the above drugs should be used according to the doctor’s prescription.