Hashimoto’s thyroiditis is gaining ground in thyroid disorders: the incidence of this disease is increasing every year, the course of the disease is long, and it can have lifelong effects. Today we talk about this disease, and the following are all clinical manifestations of endochoroidal thyroiditis: 1. Why the name is strange As this disease was discovered due to the first case report presented by a Japanese physician, and later named after him, Hashimoto’s. 2, in which people are common Women have a high incidence, the age of onset is young and middle-aged, in recent years the onset of the trend is low. 3.What are the clinical manifestations? At first, there is no special feeling, and the thyroid gland is symmetrical but gradually increases in size. There are multiple stages of hyperthyroidism, hyperthyroidism with hypothyroidism, hypothyroidism and other different manifestations, and elevated autoantibodies to the thyroid gland can be seen in blood tests. The disease is now mostly considered to be a chronic inflammatory reaction and an autoimmune disease. 4. In depth explanation These changes in performance are due to the destruction of the thyroid cells by antibodies. On the one hand, the large amount of T3 and T4 stored in the cells and not released into the bloodstream may produce the clinical manifestations of hyperthyroidism after cell destruction; on the other hand, as more and more cells are destroyed, the amount of T3 and T4 eventually tends to be depleted, i.e. hypothyroidism. Therefore, it is typical to go through such a course: (1) Transient hyperthyroidism The general course is a few months, and most of them have no clinical symptoms, not even an increase in FT4. This is related to the speed of thyroid destruction, and the rapid destruction and the release of more for a short period of time makes it easy to be hyperthyroid, which may be indicated by high antibody test values. (2) Stable phase After a transient hyperthyroidism, there will be a stable phase, after all, the thyroid gland is also the kind of organ with abundant reserves, and it is not that easy to be hypothyroid. (3) Hypothyroidism Eventually, the disease will go into hypothyroidism. 5, give some diagnostic tips The current clinical diagnosis focuses on the TPOAb in the thyroid antibody series, which is often tens of times higher, and the clinical diagnosis is mostly confirmed by a level higher than 400, commonly higher than 1000. TOPAb is an anti-thyroid peroxidase antibody, which is the preferred indicator for the diagnosis and differential diagnosis of Hashimoto’s hyperthyroidism. 6. How to treat complex manifestations Understanding that hyperthyroidism is at most transient in its manifestations, drugs such as ATD, surgery and I131 are superfluous, and ATD itself has no effect on the T3 and T4 that have been released into the blood. Beta blockers are effective. This is the amount of GD, but Hashimoto can take a smaller amount than this. Patients with good thyroid function can be treated without intervention, and methods for the autoimmune process have not yet been studied. Enter the hypothyroid phase with replacement therapy. The following summary: A study suggests that Hashimoto’s thyroiditis has a positive rate for TPOAb, TGAb, and TRAb of 90.17%, 100%, and 6.25%, respectively. In contrast, the positive rates for hyperthyroidism (Graves disease) were 30.3%, 70.21%, and 90.90%, respectively. Therefore, detection of the three antibodies is useful to distinguish early HT (Hashimoto) from GD (hyperthyroidism). TRAB is the specific antibody for the diagnosis of GD.