Sequestration therapy was first developed by the Soviet scholar A. V. Vyshnevsky. At that time, procaine was injected into the nerve trunk or soft tissues to block the external or internal “stimulation of the central formation” to interrupt the vicious cycle and play a therapeutic role, and then gradually developed to use other drugs, especially hormones to carry out closure therapy. In our country, combined with the theory of Chinese medicine, according to different conditions for acupuncture point closure therapy, and further improve the efficacy. A, the role of closure therapy 1, blocking the occurrence and development of pathological reflexes, eliminate the pathological impulses transmitted to the nervous system, to protect the nervous system. 2, eliminate muscle spasm, reduce the pain caused by spasm. 3.It can inhibit various inflammatory reactions. Including inflammation caused by infectious or non-infectious factors. Hormones cause significant reduction of inflammatory phenomena such as plasma exudation and leukocyte infiltration of capillaries, thus reducing swelling and pain. In the chronic phase of inflammation, hormones also inhibit fibrogenic activity, resulting in a reduction of soluble collagen components in tissues and a decrease in interstitial inflammation, thereby reducing and preventing the formation of adhesions and scars. Second, the operation method after skin disinfection, in the predetermined closed point with two fingers to press, fixed excoriated point and painful tendon bundle, then the needle penetration to the excoriated carbuncle point, back to absorb no blood, you can slowly infiltrate, and gradually shallow out, to the same method in its surrounding for infiltration. After removing the needle, pad with sterile gauze and gently press and rub to disperse the medicinal solution. Application of the liquid varies, commonly used for 2% lidocaine and Depo Pine suspension. Application of closure therapy 1. For periarthritis of the shoulder or general neck and shoulder pain, the first step is to find the obvious pressure pain point. After skin disinfection, inject 2% lidocaine and Depo-Provera suspension at the painful point under ultrasound guidance. Inject every 5-7 days, 5-7 days as a course of treatment, and 2-3 consecutive courses can be given. 2.Nerve root type cervical spondylosis can be treated with nerve root closure therapy in the lower neck. First, according to the clinical symptoms, signs, combined with x-ray film to determine the site of closure. Generally, there is often a more sensitive local pressure point. At the midpoint of the posterior edge of the sternocleidomastoid muscle, the transverse process of the fourth cervical vertebra can be closed, the transverse process of the sixth cervical vertebra is immediately above the clavicle, which is generally the easiest to reach, and the transverse process of the fifth cervical vertebra can be closed between the above two. The end of the cervical transverse process is forked, and the spinal nerve spans this sulcus. In order to improve the accuracy of treatment, ultrasound-guided local closure therapy is now mostly used. During closure, the patient takes a sitting position, and the head is turned to the opposite side of the neck and shoulder commonly used closure point after determining the closure site in the posterior edge of the sternocleidomastoid muscle into the needle, stabbing the transverse process. Needle 2-3cm into the transverse process can be touched, if the spinal nerve is stabbed, there is a sense of radiation numbness. If there is no blood and no cerebrospinal fluid in the retraction, 2% lidocaine and Depo-Provera suspension can be injected. Closed every other week, 3-5 times in a row for a course of treatment. 3, vertebral artery type or sympathetic nerve type cervical spondylosis can be used stellate ganglion closure therapy. The patient lies supine with the head turned to the opposite side. A local anesthetic mound is made 3 cm above the midclavicular point and at the posterior border of the sternocleidomastoid muscle, which is equivalent to the intersection of the external jugular vein and the posterior border of the sternocleidomastoid muscle. After the needle enters subcutaneously, the needle is slowly inserted against the transverse process of the 7th cervical vertebra, and the index finger of the left hand can be used to touch the transverse process of the 7th cervical vertebra as a guide before the needle is inserted. After the needle touches the transverse process of the 7th cervical vertebra, the tail of the needle is tilted backward and slightly toward the head end, so that the tip of the needle passes along the anterior side of the transverse process and turns to its anterior underside, and continues to be about 1 cm deep, or reaches the lateral side of the body of the 7th cervical vertebra after being blocked, then enter the needle a little, aspirate to make sure there is no gas, no blood, no cerebrospinal fluid, and then inject 10% lidocaine 10 ml. can be injected once every other week for 3-5 times. -5 times for a course of treatment. ‘If the puncture site is correct, an ipsilateral Horner’s sign should appear a few minutes after the puncture injection. At present, many hospitals have adopted ultrasound-guided treatment for pain management, which requires no special preparation, is immediately available, easy to master, can monitor the needle transportation process of the puncture needle in real time, and can also monitor the injection and diffusion of local anesthetic in real time, without the use of contrast, very easy to distinguish between vessels and nerves, and the possibility of intravascular or intra-neural injection of local anesthetic is small, which can further clarify the site of the lesion, such as sclerosis, and can be accurately injected into the Myofascial, can avoid pneumothorax, mistakenly injected into the blood vessels, obese patients can avoid injection into the fat, botulinum toxin sclerotherapy injection can be accurately positioned to avoid X-ray exposure, easy to operate, simple requirements, especially for tendons, bursa and joint injection is of greater value.