Once acute laryngeal edema occurs, it can deteriorate rapidly and cause fatal airway obstruction. Most patients with angioedema exhibit some degree of lip and facial swelling, and if accompanied by hoarseness and swelling of the tongue and oropharynx, this often suggests a high probability of laryngeal edema. In these patients, early tracheal intubation should be considered, with conscious sedation and semielective tracheal intubation without paralytic agents. If intubation is delayed, the patient’s condition often deteriorates within 0. 5-3 hours, showing progressive wheezing, vocal difficulties, laryngeal edema, huge tongue swelling, swelling of the face and neck, and hypoxemia. In this situation, tracheal intubation and cricothyroid puncture are already very difficult, and attempting to perform tracheal intubation will further aggravate the laryngeal edema and will most likely cause bleeding in the pharynx. The patient becomes extremely agitated due to hypoxia and is uncooperative with oxygen therapy. In diagnosing laryngeal edema, physicians should take a detailed history, perform pharyngeal and systemic examinations, and use laryngoscopic tools when necessary. Laryngoscopy 1. Infectious laryngeal edema may occur within a few hours with laryngeal pain, hoarseness, laryngeal wheezing and dyspnea, and may be accompanied by fever and chills, and sore throat, and laryngoscopy may reveal deep red edema and shiny surface of mucosa. 2, non-infectious laryngeal edema allergic and genetic vascular especially rapid onset, rapid development, patients often within a few minutes of laryngeal wheezing, hoarseness, dyspnea, or even asphyxia, laryngoscopy can be seen diffuse laryngeal mucosa edema, pale. Allergen examination After qualitative and quantitative testing of allergens (total IgE, total IgG, specific IgE, etc.) in the patient’s serum or plasma, it is determined whether the patient has allergic laryngeal edema. Inflammatory examination To determine whether the patient has laryngeal edema due to inflammation by inflammatory evidence examination.