If a patient has symptoms of chest tightness in the middle of the night, there are several conditions: 1. To be considered cardiogenic diseases, such as coronary heart disease, unstable angina, myocarditis, pericarditis, heart valve disease, hypertensive heart disease, etc. These conditions can cause ischemia, stenosis and spasm of the coronary arteries. In the middle of the night there will be symptoms of chest tightness, shortness of breath, palpitations, and even pain in the precordial region.2. For sympathetic nerve overstimulation caused by plant nerve dysfunction, patients will develop cardiac neurosis, and will also have symptoms of chest tightness and shortness of breath in the middle of the night.3. At this time, it may be caused by the dysregulation of the endocrine system in the body, for emotional excitement, severe anxiety, fatigue, staying up late, or drinking strong tea, coffee As well as alcoholism, smoking, etc., causing endocrine system dysfunction will also have chest tightness in the middle of the night. If the patient has endocrine metabolic diseases, such as hyperthyroidism, there will also be the above situation.