The symptoms of chest tightness and breathlessness in the middle of the night are mostly caused by cardiopulmonary diseases, such as bronchial asthma in respiratory diseases, and the patient’s symptoms of breathlessness are easy to occur in the evening and early morning, and can be sudden chest tightness and dyspnea, and a few patients with severe chronic obstructive pulmonary disease can also have an attack. In this case, chest X-ray or CT examination, lung function and bronchodilatation or excitation test should be completed to clarify the diagnosis. If the symptoms are caused by airway diseases, timely treatment with bronchodilators and oxygen can relieve the symptoms more quickly. Another major group of patients with heart failure may have chest tightness and shortness of breath in the middle of the night or when they are sleeping, which is clearly caused by heart disease according to the patient’s previous history of heart disease, as well as cardiac ultrasound and electrocardiogram. Chest tightness and shortness of breath in the middle of the night are serious symptoms, so it is necessary to improve relevant examinations for possible causes in a timely manner, and actively treat the symptoms after a clear diagnosis.