Sweat pore keratosis is a genetic keratotic skin disease. Diagnostic points: 1, mostly in adolescents; 2, can occur in any part of the head, face, trunk and limbs; 3, lesions vary in severity, in severe cases, large brown keratotic patches of skin all over the body, ring-shaped or map-shaped, some in a columnar arrangement, occurring in the eyelids can lead to lid ectropion, a few patients can occur on the sweat hole keratosis damage squamous carcinoma; 4, histopathology has typical keratosis imperfecta columnar cockle-like plate.