Dry and itchy vaginal opening may be caused by over-cleaning, change of own hormone level, or it may be related to some gynecological diseases. 1. Over-cleaning: such as frequent washing of vulva, long-term use of alkaline detergent or douching inside the vagina will take away sebum and mucus from vulva, making the skin of vulva and vaginal opening lose protective barrier and dry and itchy. Usually it worsens after washing, some women mistakenly think there is infection and will wash more frequently, leading to a vicious cycle. 2. Change in hormone level: For some older women or people with history of ovarian surgery, dry and itchy vagina is considered to be related to factors such as endocrine disorders and declining ovarian function, these factors lead to changes in hormone level in the patient’s body, reducing cervical and vaginal secretions and feeling dry and itchy at the vaginal opening It can be judged by hormone six or gynecological ultrasound. The hormone supplementation is guided by the doctor and daily attention is paid to keep emotional stability and avoid anxiety and anger, overwork, etc. 3. Vaginal inflammation: mostly caused by mycosis fungoides, commonly seen in women who have been taking oral antibiotics for a long time, have diabetes and have a history of mycosis fungoides. The discharge is thick and curdled or bean curd-like, with burning and itching at the vaginal opening and vulva. It can be treated by local medication after microscopic examination of the secretions to clarify the infection.