If a patient with ventricular fibrillation is encountered or detected clinically, the preferred treatment is definitely asynchronous electrical resuscitation. However, there are times when a patient with ventricular fibrillation is found to have loss of consciousness, and it is not the first time that the patient is judged to be in ventricular fibrillation. In this case, the patient with loss of consciousness is targeted for the presence of malignant arrhythmias. If unknown, chest cardiac compressions are used first to ensure the patient’s effective cardiac output as soon as possible, while contacting the nearest electrical defibrillation measure. In addition to conventional cardiac asynchronous electrical resuscitation therapy, ventricular fibrillation, if the etiology is clear, commonly used clinical drugs include lidocaine and amiodarone. If ventricular fibrillation is due to tip-twisting ventricular tachycardia, magnesium sulfate and atropine may also be considered as options.