The main causes of purple lips and numbness are as follows: 1, cold, cold weather, if you do not do a good job when you go out, may cause purple lips, numbness symptoms. 2, congenital heart disease, mainly due to heart ischemia, hypoxia, can be accompanied by cyanosis, weakness, wheezing after activity, thin body and other symptoms, can check the heart ultrasound to confirm the diagnosis. 3, heart failure. Most of the patients have a history of heart disease, such as coronary heart disease, which can be accompanied by lower limb edema, telescopic breathing, etc. Check the electrocardiogram and cardiac function to confirm the diagnosis. 4, oral administration of certain drugs, such as oral gentamicin, oral overdose of certain drugs can also cause the symptoms of numbness and purple lips. It is best to go to the hospital for further examination to confirm the diagnosis and early treatment.