Foot odor is mainly caused by the smell of infected fungi and bacteria acting together on the body, and the condition can be treated with antifungal and antibacterial drugs in concert. The antifungal cream can choose to use sertaconazole nitrate cream, miconazole nitrate cream, clotrimazole cream, terbinafine and so on. These drugs act in the body, can effectively inhibit the metabolism and reproduction of fungus, can stop its decomposition of the stratum corneum, to avoid continued aggravation of foot odor. And anti-bacterial drugs recommended to apply mupirocin cream, fusidic acid cream, erythromycin ointment, can effectively stop the value-added of bacteria, can stop the formation of foot odor due to bacterial infection, and need to pay attention to the best in daily life to wear loose, breathable shoes. This is conducive to the discharge of sweat outward from the soles of the feet, to avoid excessive humidity in the feet, repeated infections of bacteria and fungi is not conducive to treatment.