Pertussis vaccine is one of the routine vaccines in China’s immunization vaccination plan. 1 dose is given to infants at the age of 3 months, 4 months and 5 months respectively after birth, and 1 booster dose is required at the age of 18-24 months, for a total of 4 doses. It is mainly used to prevent pertussis, diphtheria and tetanus, but some infants may have some adverse reactions after vaccination: I. Local reactions: 1. Common: redness, swelling, pain and itching may appear at the place of vaccination, and a few infants may also have hard nodules, which usually do not require treatment measures and the symptoms may disappear after 2-3 days. For the swelling and pain that cannot disappear for a long time, you can also choose to apply hot compresses after the pinhole is healed, which can help activate blood circulation and remove blood stasis, and help the hard knots dissipate; 2. Rare: Very few infants may have local pus, edema, papules and other symptoms at the inoculation site, and if the pustules do not subside for a long time, it is necessary to go to the hospital to draw out the pus, and it may also be necessary to perform debridement surgery to remove necrotic tissue. Systemic reactions: 1. common: fever, low fever, headache, fatigue, muscle aches, loss of appetite, usually no special treatment, pay attention to drink more water, eat more light, easy to digest food can be, and pay attention to keep warm, avoid cold; 2. rare: very few infants may appear convulsions, convulsions, shock, abnormal crying, unable to sleep and other reactions, suggesting that the nervous system may have problems The infant should be brought to the hospital by the parents for diagnosis in order to be treated. Some infants may also develop systemic allergic symptoms such as rash and purpura, which usually require anti-allergy treatment. Note that most infants have mild symptoms that can disappear in as little as 2-3 days or as much as 1 week. If they do not disappear for a long time or if they get worse, they need to be seen in time to prevent the condition from worsening.