Diabetic nephropathy develops into uremia, the clinical indicators mainly look at the blood creatinine and estimated glomerular filtration rate, urinary protein can only suggest impaired renal function, usually unable to determine whether the development of uremia. It is generally recognized that blood creatinine more than 707μmoI/L and glomerular filtration rate <10ml/min is considered uremia. Creatinine is the metabolic end product of creatine in muscle tissue, which does not bind with protein in the blood and can freely pass through the glomerulus, and is currently the most commonly used indicator to indirectly reflect glomerular filtration function. When the glomerular filtration function is impaired, the body's serum creatinine may be elevated, suggesting the presence of renal insufficiency. When blood creatinine exceeds 707 μmoI/L, it suggests entering the uremic stage. Clinically, various laboratory data, such as urea, creatinine, cystatin C, etc., are usually applied to derive glomerular filtration rate from various formulas in conjunction with information on the patient's gender, age, and ethnicity. When the glomerular filtration rate is <10ml/min, it suggests that the patient enters the uremic stage. The presence of urinary protein in diabetic nephropathy usually suggests that renal function is impaired, but it is not possible to determine whether it develops into uremia or not, and it is necessary to combine the creatinine value and the estimated glomerular filtration rate to determine whether the patient enters into the uremic stage. Patients with diabetic nephropathy are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.