Patients with AIDS do not have characteristic manifestations in the early stages of infection and are usually consistent with normal people and cannot be differentiated. However, as the disease progresses and the patient enters the end stage of AIDS, there may be other comorbidities that may cause corresponding manifestations, the most common being a state of extreme wasting, which may be related to the long-term depletion of the patient’s AIDS base. In addition, if the patient has a combination of oral fungal infections, a large number of white spots can be found on the surface of the mouth and tongue. When the patient has a combination of fungal dermatitis, a rash may be seen on the skin of the entire body. When Kaposi’s sarcoma is present, significant gingival hyperplasia can be seen. In combination with cytomegalovirus infection of the eye, vision loss may be seen. In conclusion, patients with end-stage AIDS may have a variety of opportunistic infections and opportunistic tumors, which may manifest differently depending on the disease.