At present, the pathogenesis of myopia is not well understood and cannot be truly cured, so it is very important to control the growth of myopia in adolescents, and atropine eye ointment is one of the more effective methods to prevent and control myopia. In a large sample of clinical observations conducted by ophthalmologists in Singapore, myopic adolescents who used atropine ophthalmic ointment for 2 consecutive years had a significantly lower increase in myopia (0.12D/year vs. 0.89D/year) compared to unmedicated children with similar myopia, and no effect of atropine on retinal function was observed. , IOP and lens accommodation were not adversely affected. So what is the mechanism of atropine for myopia? It was found that the main mechanism by which atropine blocks the development of myopia is not pupil dilation, but by blocking the M-cholinergic receptor mechanism. Therefore, the pupil dilatation that occurs during this treatment is a side effect of the treatment. The search for an effective low-concentration atropine ophthalmic ointment that avoids pupil dilatation but provides effective myopia prevention and control is also a topic that myopia specialists are actively exploring. What are the considerations during atropine treatment? First, doctors need to decide whether atropine treatment is appropriate based on the nature of the child’s myopia and various eye indicators. Atropine is a good indication for children with young myopia onset, high congenital myopia, and large annual growth, but for children with hypoplasia of the anterior segment of the eye, lax crystal ligaments, and retinal dysplasia, long-term application of atropine can cause complications and should be used with caution; secondly, during the treatment process, strict follow-up observation of adverse reactions, such as work impairment in close reading, photophobia, etc., can Secondly, we should strictly follow up and observe the adverse reactions during the treatment, such as the difficulty in close reading, photophobia, etc., which can be relieved by wearing study glasses or shades; furthermore, we should pay attention to the possible allergic symptoms and systemic complications, such as facial flushing, rapid heartbeat, increased blood pressure, etc., and prohibit strenuous exercise after ordering the medication, pay attention to the control of environmental temperature, and drink more water; finally, long-term users of atropine should regularly review the development of eye indicators, and find an effective minimum concentration dose for long-term use. Lastly, long-term users of atropine need to be reviewed regularly to find the lowest effective concentration for long-term use. Short-term use of atropine is not only ineffective, but may also result in rapid growth of myopia after stopping the drug. Therefore, it is best to stop atropine treatment after the age of risk for myopia growth, such as 12-14 years.