The patient was diagnosed with decompensated cirrhosis combined with hypersplenism, ascites and coagulation disorder 11 years ago (2010). He underwent splenectomy with buried infusion port for autologous bone marrow infusion at the Shanghai Public Health Clinical Center Surgery Department. Liver function gradually improved. Today he came for autologous bone marrow cell therapy again. Most patients with this type of decompensated cirrhosis progress to liver failure in about a year if treated with conventional medication. Autologous bone marrow cell therapy has enabled patients with cirrhosis to basically recover their health. Therapy improvement Traditional autologous bone marrow transplantation for cirrhosis requires surgery to bury the infusion port and hospitalization for about a week. Recently, Prof. Liu Baochi’s team has done a therapy upgrade and perfection at the HeNuo Medical Cellular Medicine Center: implementing ultrasound-guided intrahepatic portal vein transplantation of autologous bone marrow cells for cirrhosis, realizing no open surgery, no hospitalization, and going home the same day. This improved therapy is suitable for patients with early to mid-stage cirrhosis. In addition to liver transplantation, MSC therapy and autologous bone marrow transplantation are the most effective therapies available in the international literature. Mesenchymal stem cell therapy is still in the clinical research stage in China, and no clinical treatment has been carried out yet. Autologous bone marrow transplantation therapy has been carried out by Prof. Liu Baochi’s team at Fudan University since 2009, and has treated more than 400 patients with intermediate to advanced cirrhosis so far with remarkable results: most patients have disappeared ascites, increased liver volume, and significantly improved liver function. Embryonic-like cells are present in the bone marrow. Under certain conditions, such cells can differentiate into a variety of functional cells or tissues and organs, which have a repairing effect on the damaged cells in the cirrhotic liver. Bone marrow stem cells are like seeds, and the components surrounding the stem cells are like soil. Transplanting the seeds and soil together may be more conducive to the transformation and proliferation of stem cells in the injured organ. The microenvironment of the injured organ is more suitable for the repairing effect of stem cells on autologous injured tissue cells than any laboratory simulated cell culture proliferation environment. The results of autologous bone marrow transplantation for liver cirrhosis were published in July 2013 in the international authoritative journal CellDeath&Disease, and in 2016, China News published a newsletter for this purpose, “Chinese medical experts innovate with “seed soil transplantation” method Successful treatment of liver cirrhosis”.