Tacrolimus ointment as a calcium-regulated neurophosphatase inhibitor currently shows some advantages in the treatment of vitiligo: first, Tacrolimus ointment is a non-hormonal ointment, relatively than glucocorticoid drugs can be used for a long time. Secondly, tacrolimus ointment is still effective when used on thin skin areas such as eyelids, face, vulva, etc., especially with 0.1% tacrolimus ointment. So Tacrolimus ointment is a better choice to treat vitiligo, of course for vitiligo need a variety of means combined treatment.