1.Cyclosporine A 5~6mg/kg.d, maintain blood concentration 50~150ng/ml, can be reduced to 3mg/kg.d after induction of remission Side effects: gingival hyperplasia, hirsutism, hyperkalemia, decreased renal function, interstitial nephropathy Monitoring: blood creatinine, blood potassium, renal biopsy if necessary. 2.Cyclophosphamide Cumulative amount below 250mg/kg Side effects: hemorrhagic cystitis, leukopenia, affect fertility, abnormal liver function Monitoring: blood routine, liver function 3.Mycophenolate 250~1200mg/m2/d Side effects: gastrointestinal symptoms, bone marrow suppression Monitoring: blood routine, liver function 4.Tacrolimus 0.1mg/kg/d, maintain blood concentration 5-10ng /ml Side effects: abnormal glucose tolerance, nephrotoxicity, decreased renal function Monitoring: blood glucose, urine glucose, blood creatinine, etc.