Currently, the most common first-line drug used in clinical practice for the treatment of prostatitis is antibiotics, but only about 5% of patients with chronic prostatitis have a definite bacterial infection. The choice of antibiotic is based on the results of bacterial culture and the ability of the drug to penetrate the prostate gland. The ability of a drug to penetrate the prostate depends on its degree of ionization, lipid solubility, protein binding rate, relative molecular mass, and molecular structure. The commonly used antibiotics are fluoroquinolones (such as ciprofloxacin, levofloxacin and lomefloxacin), tetracyclines (such as minocycline) and sulfonamides (such as cotrimoxazole). After the diagnosis of prostatitis, the course of antibiotic treatment is 4-6 weeks, during which the patient should be evaluated in stages of efficacy. If the results are unsatisfactory, the patient can be switched to other sensitive antibiotics. Some patients with this type of disease may have intracellular pathogens such as Chlamydia trachomatis, Ureaplasma lysis or Mycoplasma humanum, which can be treated with oral antibiotics such as tetracyclines or macrolides. Treatment with intraprostatic antibiotic injections is not recommended.