Diabetic patients with the development of the disease, weight loss is generally, the occurrence of weight gain, mostly considered with better blood sugar control, drug side effects or the emergence of diabetes mellitus serious complications such as renal insufficiency caused by sodium retention and so on. 1. Good glycemic control: If patients strictly follow the doctor’s instructions to take medication on time, the blood sugar level is in a normal state for a long time, the energy metabolism is generally in a normal state, when the patient’s energy intake is greater than the energy consumption for a long time, it is possible to have a weight gain, it is recommended that the patient in the medication to control blood sugar at the same time, to improve the eating habits, and adhere to the exercise. 2. Drug side effects: such as long-term use of insulin, Repaglinide and other drugs may lead to weight gain, such drugs can reduce urinary glucose excretion, and at the same time can promote fat synthesis, which ultimately leads to weight gain, the patient should be medication, diet, exercise to maintain the three in a balanced state, but also follow the doctor’s instructions for the joint use of Metformin, Acarbose, and other hypoglycemic drugs. 3. Serious complications of diabetes mellitus: such as renal insufficiency caused by diabetes mellitus, which will lead to water and sodium retention and then generalized edema and weight gain, patients need to be hospitalized in time to carry out the relevant treatments, and continue to use glucose-lowering drugs such as insulin, metformin, etc. under the guidance of the doctor, and severe cases need to be treated by means of hemodialysis and renal transplantation. If there is any discomfort, please consult the doctor in time.