”After examination, you have a nodule in your thyroid gland and elevated thyroglobulin, it is likely to be thyroid cancer and must be operated as soon as possible!” , listening to a doctor’s words, Ms. Wang’s legs went weak in shock and she couldn’t say anything. The ultrasound found a soy-sized nodule in the thyroid gland and the blood test showed that the thyroglobulin was twice the normal value. When she was referred to me by someone else, she was almost crying when she spoke. After detailed medical history, checklist and physical examination, I found that Ms. Wang’s thyroglobulin was indeed a bit high, but ultrasound examination did not reveal obvious signs of malignancy such as nodules with indistinct margins and microcalcifications, and the best way to clarify the nature of the nodules in this case was to do a fine needle aspiration of the thyroid gland. After receiving advice, I performed a puncture on Ms. Wang and the result was benign. Regarding the relationship between thyroglobulin and thyroid cancer, some doctors in the clinic still hold the old view that increased thyroglobulin must be a malignant lesion. Thyroglobulin is found in the thyroid follicles and can be elevated in a variety of benign thyroid diseases, including Hashimoto’s thyroiditis (chronic lymphocytic thyroiditis), painless thyroiditis, postpartum thyroiditis, Graves’ disease, thyroid adenoma, subacute thyroiditis, and nodular goiter, among others. Due to the destruction of thyroid follicles caused by these causes, the thyroglobulin in the colloid enters the blood circulation and increases the level of serum thyroglobulin, and some patients also have an increase in thyroglobulin level after thyroid physical examination touch, while some thyroid cancer patients can have normal thyroglobulin in the blood. Therefore, an increase in thyroglobulin does not necessarily indicate a malignant lesion, and normal does not exclude a malignant lesion. In clinical practice, only after total thyroidectomy, if thyroglobulin is higher than once, it indicates recurrence or metastasis of thyroid cancer. Because the serum thyroglobulin level can hardly be measured after total thyroidectomy, if thyroglobulin slowly increases later, it indicates cancer recurrence. After understanding the above knowledge, Ms. Wang was relieved and when she left the hospital, she said happily, “Thank you doctor, your words made me go back with peace of mind.” Yes, a word from the doctor makes people happy and worries them. Behind this word, how much trust and responsibility is carried.