Problems related to the use of medication during pregnancy

First of all, in the course of pregnancy October, in addition to some folic acid and iron, calcium, vitamins and other related physiological supplements, there are often cases of unplanned pregnancy and medication, or the emergence of medical and surgical diseases and the need for medication, that the following I briefly introduce, pregnant women’s drug classification, which classification, when evaluating the degree of harm of drugs to pregnant women and fetuses, based mainly on the standards issued by the U.S. Food and Drug Administration (FDA). Commonly used drugs are divided into five categories: A, B, C, D and X grades. Class A: no harm to the fetus has been observed by clinical control, which is the safest category; Class B: no harm to the fetus has been observed in animal tests, but there is a lack of clinical control observation data; or harm to the fetus has been observed in animal tests, but clinical control observation studies have failed to confirm; Class A and B drugs are drugs that are not or almost not harmful to the fetus and pregnant women, and can generally be used safely during pregnancy, such as a variety of vitamin class and calcium preparations, and some antibiotics, such as penicillin family, cephalosporins, etc. Class C: animal experiments and clinical control observation data are not available; or there is damage to animals and fetuses, but lack of clinical control observation data. The choice of these drugs is most difficult, and many drugs commonly used during pregnancy belong to this category; Class D: there is a certain amount of clinical data indicating that the drug is harmful to the fetus, but the clinical need is very important, and there is a lack of alternative drugs, then the decision can be made by weighing the severity of the harm and clinical indications; Class C and D drugs are harmful to the fetus (teratogenic or abortive), but beneficial to pregnant women, must be used carefully after weighing the pros and cons. Such as some antibiotics, hormones. Class X: animal experimental results and clinical data indicate that the fetus is harmful, generally has exceeded the beneficial benefits achieved by the therapeutic application, belong to the drugs prohibited during pregnancy; these drugs are seriously harmful to the fetus and are prohibited during pregnancy, such as anti-cancer drugs, sex hormones (synthetic estrogen, synthetic progestin), etc. However, Class A and B drugs are not guaranteed to be absolutely safe because there are individual differences among pregnant women. Moreover, due to the limitations of basic and clinical research, there are many drugs that have not been graded. Therefore, when you have to use drugs during pregnancy when your body has abnormalities, your doctor can only choose drugs that have less impact according to this drug classification, but your doctor cannot guarantee absolute safety, and can only try to help you. Because some patients, the pregnancy is also very difficult, also can not easily abort him. So it is also up to you to make your own choice. But according to the principle of medication, as long as the medication is used under the guidance of the doctor, the disease improves, and the medication is stopped in time, it is generally safe. Next, let’s talk about the effects of drugs on the fetus in various periods of pregnancy. After fertilization 1~2 weeks (i.e. 3~4 weeks of menopause): the effect of drugs on the embryo is “all or nothing”, i.e. either no effect or an effect leading to miscarriage, generally will not lead to fetal malformation, so when you take drugs before pregnancy or early pregnancy period when you do not know if you are pregnant, generally will not have too much effect on the fetus, do not worry too much It is not necessary to have an abortion because of this. 3~8 weeks after fertilization (i.e., 5~10 weeks after menopause): called teratogenic sensitive period, is the period of embryonic organs differentiation and formation, very susceptible to drugs and other external factors that lead to fetal malformation, this period does not need to use drugs, including general health care products, tonic drugs. If you have to use drugs, be sure to use them carefully and safely under the guidance of a doctor. If you have a history of taking medication, prenatal diagnosis (including ultrasound) can be performed at 16-20 weeks of pregnancy to further understand fetal growth and development and to rule out fetal abnormalities. Mid to late pregnancy (i.e. after 12 weeks of menopause): This is the period when the fetal organs are basically differentiated and continue to grow. The possibility of teratogenicity of drugs decreases greatly during this period, but some drugs may still affect the normal development of the fetus. Before delivery: Pregnant women should also pay close attention to the last week of drug use, because when the fetus becomes a newborn baby, the body’s metabolic system is not perfect, it can not quickly and effectively handle and eliminate drugs, drugs may accumulate in the baby’s body and produce drug overdose performance. For example, dysentery can inhibit the hematopoietic function of newborns, cause jaundice, hemolytic anemia, etc.; some can cause hypoglycemia in newborns; some can even lead to fetal death. In summary, patients must combine the above two and make their own preliminary judgments, so that you do not remain worried after being prescribed medication because your doctor is busy. For example, if a drug is a class B, it is relatively safer when used at 3-4 weeks of menopause, or greater than 10 weeks.