Darkening of the skin in the toe area requires careful determination of the cause based on clinical symptoms.1. If the darkened area has reduced pain and tactile sensation, consider the possibility of frostbite or diabetic foot caused by diabetes. If there is an obvious cold source of contact, it should be frostbite, and it is recommended to choose gradual rewarming with topical frostbite cream. The diabetic foot, if there has been a state of blackened toes, it is necessary to go to surgery, if necessary, amputation. 2, if the blackened place feels all right, simply appear obvious itching, skin surface erythema, papule-like changes, consider the possibility of chronic eczema, this situation is directly related to allergies, irritation, it is recommended to choose to use Denide cream with zinc oxide cream comprehensive treatment 3, if the blackened skin does not have any self-perceived symptoms, all normal, consider the possibility of hyperpigmentation or melanosis, you can choose to take oral glutathione topical hydroquinone cream.