1.Born less than 3 months 2.Body temperature over 40 degrees for 24 hours 3.Body temperature over 38.5 degrees for 72 hours 4.Vomiting and diarrhea, convulsions, difficulty swallowing, shortness of breath, blue lips 5.Poor mental activity, irritability or depression, lethargy 6.Dehydrated state: dry mouth, few tears, little urine 7.Headache, stiff neck, full fontanel 8.Fever receding 24 hours body temperature rise again