Over the past few decades, gender differences among alcohol-dependent patients are diminishing. A new study shows that alcohol abuse causes nerve damage faster in women than in men, while a number of studies have found that women have more serious physical problems from excessive alcohol intake than men, and that female alcohol-dependent people are more likely to develop psychological disorders. How to get women to quit drinking safely? The patient, Ms. Tang, is 34 years old and has been drinking heavily for 10 years and cannot quit on her own. Now, in order to quit drinking for good, she came to our department and was admitted to our clinic as “alcohol dependence”. Since her admission to the hospital, Ms. Tang has been conscious, cooperative, and in good spirits. She says she is now deeply aware of the dangers of alcohol abuse, but her long-term heavy drinking has made her dependent on alcohol and she cannot quit on her own. He hoped that he could get rid of his dependence on alcohol with the treatment of surgical withdrawal at Tangdu Hospital. Based on the patient’s condition, Professor Wang Xuelian performed stereotactic intracerebral multi-targeted radiofrequency disruption to control the patient’s dependence on alcohol through surgical treatment. The operation was performed under general anesthesia, and the head locator was placed. The anatomical localization of the head targets was performed under 64-row CT, and the intracranial structures were clear. The scalp was incised 4 cm longitudinally with a mastoid retractor, and the skull was drilled and the bone margins were coated with bone wax. The dura was incised crosswise, and the cortex was electrocautery to stop the bleeding completely. A stereotactic positioning device was placed, and the surgical targets determined according to the preoperative positioning were the bilateral vomeronasal nuclei and the anterior limb of the internal capsule, and radiofrequency electrodes were placed for treatment. After the treatment was completed, the electrodes were removed, and the bone holes were closed with gelatin sponge after repeated flushing with hydrogen peroxide and saline. The capitellum and scalp were sutured and bandaged in layers. The patient did not bleed much during the operation and his vital signs were stable. Dr. Wang Xuelian, the chief physician, instructed that postoperative treatment was given to prevent infection, hemostasis, neurotrophic, nutritional support and symptomatic support, and changes in condition were closely observed. On the first postoperative day, the patient was conscious, poor in spirit, and had no complaints of headache, nausea, vomiting and other discomfort. There was no obvious abnormality of limb movement and sensation, dry head dressing, and no abnormal exudation during physical examination. Dr. Wang Xuelian, the chief physician, instructed that the patient’s condition was stable after the operation, stopped cardiac monitoring and oxygenation, and continued to give symptomatic support treatment such as hemostasis and fluid replacement. On the second day after surgery, the patient’s vital signs were stable, and there were no complaints of headache, nausea, vomiting and other discomforts, and the wound was healing well without exudation. Professor Wang Xuelian inspected the patient and instructed: the patient recovered well after surgery, no obvious discomfort, continue to give hemostasis, nutritional support, neuroprotection and other treatments. Close observation of changes in the condition. Afterwards, the patient, Ms. Tang, recovered well in the hospital. After the surgical cessation, the patient did not have the urge to drink again, and the surgical effect was very obvious. Introduction to the principle of surgical alcohol cessation The principle of surgical alcohol cessation is the same as the principle of surgical detoxification, both using a kind of localized targeted destruction based on modern physiological techniques and cellular localization, with remote sensing microdetermination of location, computer control, through the analysis of electrical signals in brain cells, and supplemented by advanced image diagnostic techniques such as MRI and spiral CT, so as to determine the best surgical cause of addiction “target”, and then eliminate the addictive cells in the patient’s brain with radiofrequency heating to achieve the purpose of treatment.