In clinical practice, it is very dangerous if a patient develops posterior tibial vein thrombosis because posterior tibial vein thrombosis is a deep vein thrombosis. If patients develop posterior tibial vein thrombosis, they will be prone to dislodge the posterior tibial vein thrombosis, which will lead to the occurrence of pulmonary infarction. Once the pulmonary infarction occurs, the patient will experience chest tightness, dyspnea, cough and other discomforts within a short period of time, which sometimes affects the patient’s life safety. Therefore, in clinical practice, once a patient develops posterior tibial venous thrombosis, anticoagulation and thrombolytic therapy must be actively given. Generally, commonly used anticoagulants include low-molecular heparin sodium, warfarin, rivaroxaban, dabigatran, etc., and commonly used thrombolytic drugs include streptokinase, urokinase, etc. During the treatment period, patients should preferably rest in bed, elevate the affected limbs, and do not massage the lower limbs of patients to prevent stimulating the dislodgement of blood clots and causing patients to develop pulmonary infarction.