Diabetic patients with swollen feet, swollen face for many years need to consider may be related to diabetic nephropathy, diabetic cardiovascular lesions and other disease factors, may also be caused by drug factors, it is recommended to seek medical attention in a timely manner. 1. Disease factors: diabetic patients with long-term poor glycemic control may cause cardiovascular lesions, the development of heart failure can occur when swollen feet, swollen face and other symptoms. Long-term poor glycemic control may also induce diabetic nephropathy, proteinuria. Proteinuria may cause hypoproteinemia, which ultimately leads to swelling of the face and feet. 2. Drug factors: diabetic patients who are taking glucose-lowering drugs such as rosiglitazone and pioglitazone may experience the adverse effects of edema. Diabetic patients with swollen feet and swollen face are advised to go to the hospital and ask the doctor to make a judgment, and should not judge blindly on their own.