The diagnosis of early cirrhosis can be made by meeting one of the following four diagnostic criteria: 1. Liver puncture examination suggests liver fibrous tissue hyperplasia and fibrous separation and encapsulation to form pseudo lobules, which is the gold standard for the diagnosis of cirrhosis. 2. Ultrasound or CT suggests signs of cirrhosis, such as liver volume reduction, widening of liver fissure, etc.; or there are signs suggesting portal hypertension, such as portal vein, splenic portal vein widening, splenomegaly, etc. 3. If the above tests are not done, the diagnosis can be made if two or more of the following laboratory indicators are met: firstly, platelet count less than 100,000 and other causes are excluded; secondly, albumin count less than 35g to exclude malnutrition and kidney disease; then the international standardized ratio of coagulation is greater than 1.3 and finally, the ratio of glutathione to platelets is greater than 2.