Liver palms and spider nevus appear at the same time when the patient needs to pay attention to rest and nutrition, quit smoking and drinking, avoid the use of liver-damaging drugs, if necessary, follow the doctor’s instructions to treat the liver pathogenesis. Liver palms and spider nevi are mostly caused by cirrhosis, decompensated liver function leading to estrogen inactivation obstacle, resulting in increased estrogen expansion of small arteries. 1. Patients should pay attention to rest and nutrition, bed rest, avoid exertion, and exercise appropriately when the symptoms improve. 2. Patients need to quit smoking and drinking, alcohol will further aggravate liver damage; at the same time, avoid the use of liver-damaging drugs. 3. Treatment of primary disease: Cirrhosis caused by viral hepatitis needs antiviral treatment at the same time, taking liver-softening drugs at the same time, and taking liver-protecting drugs if there is liver function abnormality; if there are complications, such as esophagogastric fundus varices, ascites and other complications, we should treat for the complications. When liver palms and spider nevi appear at the same time, it is necessary to consult a doctor in time and carry out standardized treatment under the guidance of a doctor.