A patient’s chronic lack of hunger is actually a manifestation of loss of appetite, or indigestion, and can be caused by a variety of reasons. The first consideration is that it may be due to depression, anxiety, restlessness, tension, anger and other emotions, the central nerve of the brain for food demand is reduced, which leads to the performance of anorexia and refusal to eat. In addition, it may also be due to drug side effects, digestive tract diseases, systemic diseases, etc.: a. Drug side effects: If patients take long-term or even excessive ammonium chloride, digitalis, chloramphenicol, aspirin and other drugs, it may induce uncomfortable reactions in the digestive system, and patients will have a series of adverse reactions such as obvious loss of appetite and nausea. Usually, the symptoms will improve significantly after the patient stops taking the medication. Gastrointestinal diseases: 1, gastrointestinal diseases: If patients are induced by bacterial infection, trauma, uneven diet and other factors, gastritis, enteritis, gastric ulcer, gastroesophageal reflux, intestinal obstruction, gastrointestinal tumors and other conditions, there are often clinical manifestations of loss of appetite, nausea, vomiting, belching, etc.; 2, hepatobiliary diseases: common hepatitis, cholecystitis, cirrhosis, bile duct tumors, liver cancer, etc., can cause patients bile secretion The abnormal bile secretion can have an important impact on the digestive function, which can easily lead to indigestion, resulting in long-term bloating, nausea, loss of appetite and other discomforts; 3, pancreatic diseases: pancreatitis, pancreatic tumors and other pancreatic tissue lesions, resulting in pancreatic fluid secretion disorders in the patient’s body, often with abdominal pressure, bloating, frequent vomiting, fever, loss of appetite and other clinical manifestations, and prolonged Long-term loss of appetite can also cause malnutrition. Systemic diseases: Hypothyroidism, hypoadrenocorticism, hypokalemia, anemia, uremia and other systemic diseases can cause hormone level disorders, as well as metabolic acidity and alkalosis, which can lead to decreased appetite and lack of hunger. Due to the relative complexity of the situation, patients are advised to seek medical attention in a timely manner to have the specific cause evaluated by a physician and treat the cause in parallel, thus alleviating the symptoms of long-term lack of hunger.