Liver fibrosis is a trauma healing response of the liver to liver injury due to various causes, and is a necessary stage in the development of chronic liver disease to cirrhosis. 1.Patients with various chronic viral hepatitis are at high risk of developing liver fibrosis and cirrhosis. 2, patients with repeated infections of schistosomiasis are often prone to portal liver fibrosis. 3, alcoholism and long-term alcohol drinkers in the liver acetaldehyde produced by the direct poisoning of liver cells, the initial cause of fatty liver, later can develop into liver fibrosis, cirrhosis. 4.Patients with primary and secondary chronic intrahepatic cholestasis can produce cholestatic liver fibrosis. 5.Patients with hepatomegaly and hemochromatosis can produce metabolic liver fibrosis. 6, Long-term exposure and intake of various toxic substances can cause toxic liver fibrosis. 7, people who prefer low protein diet and meat frying food can produce nutritional liver fibrosis. 8, chronic congestive heart failure patients can produce cardiogenic liver fibrosis. 9, various causes of liver fibrosis, if not timely diagnosis and treatment, it will cause cirrhosis.