The treatment of intestinal flora disorders requires a combination of measures to remove the cause and the administration of microecological regulators. Specific to do the following: 1, find and remove the causative factors: for specific pathogens such as chronic bacillary dysentery caused by Shigella, enteritis caused by fungi, pseudomembranous enteritis caused by Clostridium difficile, etc., need to choose sensitive antibiotics for treatment; if there are difficult to remove the causative factors such as the use of immunosuppressive agents after organ transplantation, tumor patients undergoing radiotherapy, etc., should strengthen the corrective treatment. 2, the management of antibiotic use: due to the use of antibiotics, especially broad-spectrum antibiotics resulting in dysbiosis, to stop the use of broad-spectrum antibiotics or switch to narrow-spectrum sensitive antibiotics under close observation. 3, improve the patient’s systemic condition: the improvement of the systemic condition is closely related to the adjustment of the intestinal flora itself, pay attention to improve the patient’s systemic condition through various treatments. 4, adjust the diet: diet should pay attention to eating fresh and easily digestible food, not too much food at one time, and ensure enough vitamins. For corrosive diarrhea, a high-carbohydrate and low-protein diet can be adopted, and for fermentative diarrhea, a high-protein and low-carbohydrate diet should be adopted. 5. Micro-ecological regulators are taken: The main purpose of using micro-ecological agents is to increase the content of beneficial bacteria such as Bifidobacterium and Lactobacillus and restore the balance of intestinal flora. To prevent the occurrence of intestinal flora disorders, we should strengthen the management from both inside and outside the body. Patients suffering from chronic wasting diseases and do have infections (such as Mr. Cai mentioned in the letter) should strictly grasp the indications when using antibiotics, make drug sensitivity test, select the most sensitive narrow-spectrum antibiotic treatment in a targeted manner, and try to give drugs outside the intestine, and the dosage should not be too large, the course of treatment should not be too long, and the long-term use of a large number of broad-spectrum antibiotics without reason should be eliminated. The elderly, infants and children and the weak after the disease can use antibiotics or hormones along with micro-ecological regulators and appropriate amount of vitamin supplements.