Orlistat is a potent and long-lasting weight loss preparation, which achieves weight loss by directly blocking the body’s absorption of fat from food, so that the amount of absorbed calories and fat is less than the amount consumed, and the body’s fat storage is reduced. If patients do not experience weight loss after taking Orlistat, it may be due to the following reasons: 1. Low dosage: It is recommended that patients choose the dosage of Orlistat under the guidance of a doctor and according to their own constitution, because Orlistat is a long-lasting weight-loss medication, and if the dosage is too low or the time is shorter there may not be any noticeable changes in body weight, but it is also not recommended that the patients increase the dosage on their own, which may cause liver and kidney function and endocrine abnormalities and other adverse reactions; 2, excessive fat intake: orlistat is by reducing the amount of fat intake, so that it reaches an imbalance with the amount of fat consumed to play a role in weight loss, if the patient’s intake of fat is too much or the amount of fat consumed is too little, the body weight may not be reduced; 3, metabolic abnormalities: if the patient has metabolic abnormalities of disease, such as hypercortisolism, hypothyroidism, Polycystic ovary syndrome, etc., and caused by obesity, usually, the use of orlistat can not make weight loss, the need for treatment of the primary disease to improve the symptoms of obesity; 4, the proportion of food abnormalities: orlistat is to inhibit the absorption of fat, does not affect the absorption of carbohydrates, if the diet is mainly carbohydrates, the efficacy of its treatment will be inconspicuous. It is recommended that patients use orlistat under the guidance of a doctor, so as not to cause damage to the patient’s organism due to improper dosage. Long-term use of diet pills, or even unauthorized use, may cause some harm to the body, and patients are advised to reduce their weight by reasonably matching their diet and moderately increasing the amount of exercise.