Mild fatty liver with elevated transaminases is mainly treated with lifestyle changes and also with medications. Fatty liver is the most common liver disease in China. Patients usually have no clinical manifestations, and a few patients show right upper abdominal discomfort, etc. In severe cases, liver function abnormalities, jaundice, hepatomegaly and other manifestations will occur. For patients with mild fatty liver disease, the current main treatment is to change the lifestyle, such as controlling diet and enhancing exercise. If the patient is combined with elevated transaminases, oral liver-protecting drugs, such as dicyclomine, can be taken while improving diet and lifestyle and exercise, while avoiding drugs for liver injury. If fatty liver with elevated aminotransferases occurs, it is recommended to consult a specialist hospital, and the specific medication should follow the doctor’s instructions.