Zhao Li (a pseudonym), in her early forties, had recurrent mouth ulcers three years ago, and always thought they were caused by fire, and that she would get better with a good rest and a lighter diet. I never thought that the ulcers would last for three years, and she eventually went completely blind as a result. The disease that tormented Zhao Li is called “Silk Road disease”. What is “Silk Road Disease”? Can oral ulcers really cause blindness? Why is it that mouth ulcers, which almost everyone has had, have become so frightening? Recurrent mouth ulcers are the most common of all mouth sores, and “mouth sores” are commonly known as “mouth ulcers. The scientific name of this disease is “oral mucosal ulcer” is the most common disease in oral diseases. “Clinically, oral ulcers are benign and malignant, most patients are benign, and recurrent oral ulcers are most common, the patients are mostly young and middle-aged.” The clinical mouth ulcers, mostly refers to recurrent oral ulcers, often recurrent, sometimes a long, sometimes a dozen can grow, burning pain, but it has a self-limiting, to a certain point will “not cure”. ”The other is called traumatic mouth ulcers, mainly caused by oral irritation, such as oral root remnants, sharp edges of the teeth, misaligned teeth wear. Some people are used to cheek biting, lip biting, these bad habits can also lead to ulcers.” This type of mouth ulcer patients are mostly middle-aged and elderly. Some elderly people’s teeth are like “broken walls”, repeatedly rubbing the mucous membrane; others have improperly fitted dentures, or dentures used for 10 years are not replaced, repeatedly rubbing the oral mucosa, eventually causing bedsore ulcers. Those pain is not obvious, the edge is not clear, and the old does not heal the mouth ulcers, must pay attention to. “Especially oral ulcers that repeatedly occur in the same area are likely to be a sign of cancer. For example, tongue cancer, gum cancer and cheek cancer are all relatively common among oral cancers nowadays. As we age, our health condition deteriorates and our immune system is easily imbalanced, the chance of malignant diseases will increase. Clinically, nearly 10% of patients with difficult to heal mouth ulcers have developed cancer. This is related to many of their bad habits, such as long-term smoking, chewing betel nut, tolerating pain without timely medical treatment, etc.” The cause of mouth ulcers is complex and involved in the whole body Why Zhao Li will be blinded by mouth ulcers? It is understood that the “Silk Road disease”, medically known as “Leukocyte’s syndrome”, belongs to the immune system diseases, is a kind of vasculitis. The incidence of this disease in Japan, China, Turkey, Iran and other places is high, the scope of the disease and the ancient Silk Road route basically coincides, so the name “Silk Road disease”. The disease is rare, but it can easily lead to systemic lesions throughout the body, and in severe cases can lead to complete blindness, brain atrophy and even death, and mouth ulcers are one of its symptoms, which can also cause rashes, joint pain, eye inflammation, abdominal pain and diarrhea, dizziness and nausea. ”In fact, there are still many diseases that are implicated when looking at mouth ulcers as a symptom. In addition to ‘Leukocerebrosider’s syndrome’, another relatively rare ‘Crohn’s syndrome’, but the intestinal inflammatory disease, mostly related to genetics, patients also often show recurrent ulcers, difficult to cure. Even patients with what we often call gastric ulcers can also have oral ulcers triggered by H. pylori and streptococcal infections in their bodies.” Mouth ulcers can be seen as a manifestation of a physical condition that is likely to reflect a major problem. The causes of mouth ulcers are complex, but the following aspects have been found to be clinically relevant: first, mental factors, such as long-term stress and mental tension, which are the most common clinical triggers; second, immune disorders; third, endocrine changes, such as women before and after menstruation, mouth ulcers are prone to recurrence; third, accidental injuries, the use of roughly made dentures, toothbrushes, eating food that is too hot or accidentally biting yourself, all Fourth, nutritional deficiency or anemia, especially lack of iron and B vitamins. The people who love to eat spicy and other irritating food, acid or partial food, are also more likely to be entangled in ulcers; five is genetic factors, such as one of the parents has suffered from the disease, the chances of their children getting the disease is 35%-40%; six is allergies, such as food, drug allergies, etc. Mouth ulcers should be prevented and treated early. Benign mouth ulcers generally heal on their own in a few days to a few weeks, but it can happen repeatedly with some regularity. Malignant mouth ulcers will have a progressive development momentum, do not heal for a long time, and many recur in the same area. Recurrent attacks in the same area, difficulty in healing on its own, and a harder bottom of the ulcer can be seen as the main characteristic of cancer. Mouth ulcers are prone to recurrence, so prevention is important. People who are prone to develop them should pay attention to oral hygiene and establish good eating habits. First, reduce the stimulation and friction to the oral mucosa, do not eat food that is too hot, try to eat less irritating foods such as chili, vinegar, ginger, onion, star anise, curry, and hot fruits such as citrus, eat less fried products such as fried ribs, fried chicken legs, and other foods that are too rough and hard, and quit smoking and alcohol. Again, pay attention to balanced nutrition and increase the intake of fruits and vegetables in order to replenish a variety of vitamins and minerals. During ulcer attacks, eat small, frequent meals and semi-liquid food. After each meal, rinse your mouth with salt water, saline or medicated mouthwash to prevent food residues from aggravating secondary infection. Be regular in your daily life, adhere to physical exercise, and keep your bowels open. Keep a happy mood, get enough sleep, and avoid excessive fatigue. Women should pay attention to more rest during and before and after their periods. Toothbrushes should be bought with soft bristles, frequent oral examinations, and timely repair of bad teeth. Toothpaste should try to pick the one without sodium lauryl sulfate component.