Various risk factors that cause autologous coronary atherosclerosis can or exacerbate graft vascular disease after surgery. Such as hypertension, hyperlipidemia, hyperglycemia, etc. Therefore, for these predisposing factors, you need to adhere to the medication after surgery to slow down the development of the disease, try to prolong the life of the bridge vessel, and maintain good health. Specifically, the following drugs can be chosen: 1, antiplatelet drugs: in order to reduce thrombosis in the bridge caused by endothelial cell damage and platelet activation, antiplatelet drug therapy is very important. The most commonly used antiplatelet drug is enteric-coated aspirin, with a routine dose of 100-300 mg per day, which is generally recommended to be taken for life after surgery. Pay attention to any gastrointestinal reactions and contraindications to the drug during administration. 2, nitrates: can dilate blood vessels, reduce cardiac load, selective expansion of coronary blood vessels, improve myocardial blood supply. Commonly used nitroglycerin, isosorbide nitrate, isosorbide mononitrate and so on. 3, lipid-lowering drugs: transplantation of blood vessels, especially venous material is very easy to occur vascular sclerosis, control of blood lipids can effectively reduce the occurrence of clinical events. It is better to lower the blood lipid index to below normal. Commonly used lipid-lowering drugs are tartrazine, such as Lipitor and Sucralfate. However, regular review of liver function is needed, and due to individual differences, the liver function of some patients is significantly affected. 4, antihypertensive drugs: after surgery, blood pressure is best maintained at a normal level, if often higher than 140/90mmHg, should receive antihypertensive treatment, commonly used drugs are angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, β-blockers, the above two are recommended to be taken at the same time, and a number of clinical trials have proved that it is very necessary. If flexor arteries are used in the bridging vessels, calcium antagonists are recommended to be taken for more than six months to prevent spasm of the flexor arteries, and they can also be used as antihypertensive drugs. Among them, angiotensin-converting enzyme inhibitors produce a complication of dry cough in some patients, and should be switched to other classes of drugs in severe cases. Beta-blocker regulation should be carried out under the guidance of a doctor. 5, hypoglycemic drugs: diabetic patients must strictly control blood sugar. Oral preparation or subcutaneous injection of insulin can be used, insulin pumps can also be selected, the initial regulation of blood glucose should be carried out under the guidance of a doctor, the patient has mastered the regulation methods and laws and then regulate their own, and try to control the blood glucose within the normal or slightly higher range. 6, other auxiliary drugs: such as gastric mucosa protector, antacids, hepatoprotective drugs and so on according to the individual choice, but before using the best consult a specialist. Avoid adverse reactions or synergistic effects of taking too much medication.