Most burns are mild and do not require admission to the hospital. Blisters can be a sign of a superficial second-degree or a deep second-degree burn. Should it be clipped? First let’s look at the role of the blister itself and the function of the blister fluid . The blister itself protects the underlying dermal wound tissue from external bacterial invasion, reduces pain and repeated dressing changes, and also confers a moist, i.e., healing-friendly, environment on the wound. In the 1950s and in today’s harsh environment, preserving blisters is an effective treatment. Blister fluid contains many biological complexes (Prostaglandins, thromboxanes, oxygen free radicals) that inhibit lymphocyte immune function and microcirculation. The epithelial tissue of the blister itself is a necrotic tissue, which can agglomerate the infection. Removal of the dead skin of the blister can reduce the infection. Dressing with modern dressings (dressings that remain in place for a week) can provide a moist healing microenvironment and is the preferred choice of many physicians today. So what exactly should be done? 1. Blisters less than 6mm, hands, and feet that are thicker can be left uncut to reduce pain. 2.Thinner blisters larger than 6mm, blisters that hinder movement, should be cut to reduce the chance of infection, improve regional immune function and promote healing. 3.The use of synthetic biological new generation dressing can maintain a moist microenvironment for cell growth and reduce the number of dressing changes to enhance healing.