Diabetic peripheral neuropathy thumb color may be normal color in the early stage, and in the later stage, the skin color may become darker, blue, black and so on. Diabetic peripheral neuropathy in the early stage usually does not have finger color changes, but only changes in sensation, manifested as numbness of the hands, feet, coldness, pain, or a glove, sock-like sensation, and some patients have the sensation of stepping on cotton. Diabetic peripheral neuropathy in the late stage involves the peripheral blood vessels, resulting in insufficient blood supply to the fingertips, there may be finger skin color darkening, blue, black, when combined with the diabetic foot can be hyperpigmentation, ulcer formation, gangrene of the fingertips and other manifestations. Diabetic patients usually need to control blood sugar strictly to prevent or delay the occurrence of diabetic complications. Thumb color change should be timely consultation, under the guidance of the doctor’s treatment, to avoid delaying the condition.