Fever caused by thrombosed external hemorrhoids is mostly due to co-infection, which can be treated with antibiotics and non-steroidal anti-inflammatory drugs. Thrombosed external hemorrhoid belongs to a kind of external hemorrhoid, mainly due to venous thrombosis or venous rupture bleeding, the anus can be seen as a swelling. Acute attack is mainly manifested in the anus localized severe pain, obvious foreign body sensation. Thrombosed external hemorrhoids fever symptoms, mostly considered for hemorrhoidal mass rupture caused by infection, can be anti-infective treatment and antipyretic treatment. Before the results of drug sensitivity are not clear, broad-spectrum antibiotics can be used, such as ceftriaxone, amoxicillin, levofloxacin and so on. Non-steroidal anti-inflammatory drugs (NSAIDs), such as acetaminophen and diclofenac sodium, may be used to relieve fever and pain. Specific medication is recommended to be used under the guidance of a professional doctor, and in severe cases, surgical excision of external hemorrhoids is recommended, and anti-inflammatory care treatment is given after surgery.