1.Is it safe to use hormones in the nasal cavity? At present, the most commonly used drugs for allergic rhinitis and nasal polyps are glucocorticoids used locally in the nasal cavity. Glucocorticoids have obvious anti-inflammatory, anti-allergic and anti-edema effects, which can promote the recovery of the diseased nasal mucosa to normal. Many patients are afraid of hormones, and they have the feeling of “talking about hormones” because they think the side effects of hormones are too great and are unwilling to accept hormone treatment. In fact, there is a misunderstanding here. The hormones that we usually come into contact with refer to the systemic glucocorticoids (injected or oral), whose side effects are really not to be underestimated. For example, the dose of the commonly used nasal hormone Nesuna Spray is about 1‰ of the oral or injectable dose, and the amount of the drug that can really enter the whole body is less than 0.1% of the dose used, so the drug is approved by the FDA for use in children over 2 years old. Moreover, research data shows that the use of recommended doses of nasal hormones such as Nesuna has no effect on the growth of children, so the safety of nasal hormones is very high. Of course, it does not mean that nasal hormones do not have any side effects. A small number of patients may experience nasal dryness and nasal bleeding, which can be alleviated by using some nasal oils at the same time. In clinical practice, I have also found that a very small number of patients have developed nasal septal perforation after long-term use of nasal hormones, which is mostly related to incorrect nasal spraying methods. 2.How to use nasal glucocorticosteroids correctly? How to use nasal glucocorticosteroids? First of all, patients should master the correct nasal spraying method. Generally speaking, the left hand should be used to spray the right nose and the right hand to spray the left nose, so that the drugs can enter the deeper part of the nasal cavity better and the effect of the drugs can be better exerted. It is usually recommended to use it in the morning around 8:00 a.m. because the normal level of adrenocorticotropic hormone secretion is low and the concentration of inflammatory mediators is high, which not only can better suppress the inflammatory response but also minimize the adverse effects of nasal hormones. The doctor may also increase the number of times of medication according to the severity of allergic rhinitis and the condition of the mucosa of the surgical cavity after nasal polyp surgery. If the severity of allergic rhinitis or the post-surgical mucosal edema is more serious and there are more vesicles or granules, it may be increased to 2 to 3 times a day; in addition, in terms of the cycle of medication, generally speaking, nasal hormones should be used continuously for 2 to 3 months after nasal polyp surgery, 1 to 3 times a day Then, with the recovery of the surgical mucosa, the number of times of medication is gradually reduced, such as to 1 time every other day, until the mucosa returns to normal and then the amount of preventive medication is changed to 2 times a week, for allergic rhinitis doctors will gradually reduce the amount of medication for patients according to symptom control and examination.