Erythema keratosis is a rare genetic disease caused by genetic defects, and currently there is a lack of effective clinical cure, mostly based on symptomatic treatment, which mainly includes daily care and medication: 1. The skin should be dry and clean. Second, patients should avoid excessive skin friction, sun exposure, hot and cold stimulation, trauma and other aggravating factors. In addition, the patient’s diet should be light, avoid spicy, irritating food to prevent the rash aggravation; 2, drug treatment: first of all, the main external medicine, the patient can be under the guidance of the doctor topical eczema cream, cod liver oil ointment and other relief. The topical glucocorticoid can be used topically, with phototherapy has a certain effect. For rashes with more pronounced itching, oral antihistamines can be given in conjunction. If topical application is not effective, patients can also improve by taking oral Avelox capsules and isotretinoin pills. However, it is important to note that isotretinoin pills are more likely to affect blood lipids and liver function, and should be monitored closely during use. In addition, for rashes with more pronounced itching, patients can be treated with antihistamines. However, since patients with these diseases have poor immune function, they should not use the drugs blindly to produce adverse effects.