Chemotherapy is a very common method of anti-tumor treatment. Chest tightness and shortness of breath after chemotherapy need to be considered as factors affected by chemotherapy. The most common reactions of chemotherapy are gastrointestinal reactions and bone marrow suppression reactions, and other causes of chest tightness and shortness of breath should be considered. If the lesion itself is caused by factors, such as lung lesions, if chemotherapy alone, chemotherapy drugs do not play a corresponding effect, or will be chest tightness, shortness of breath, you can apply some anti-inflammatory, asthma, cough and phlegm drugs, while oxygen therapy can improve chest tightness, shortness of breath. Of course, chemotherapy drugs also have some cardiotoxicity, may also cause some chest tightness, shortness of breath, can do electrocardiogram, cardiac ultrasound and other checks, to understand whether there is this problem, and then symptomatic treatment.