In general, anti-inflammatory drugs have no effect on vaccination, but if the patient has acute inflammatory manifestations such as fever or diarrhea, vaccination is not suitable. Vaccines are usually injected into the body to produce substances that stimulate the immune system and generate corresponding antibodies to prevent and control diseases, while anti-inflammatory drugs generally have no effect on the immune function of the body, so they usually do not affect the effect of vaccines, and few anti-inflammatory drugs react with vaccines and produce adverse reactions. However, if the person receiving the vaccine is a child or a person with a weaker body, it is recommended to consult the relevant authorities whether it is possible to receive the vaccine after taking anti-inflammatory drugs because the resistance may be lower. Although anti-inflammatory drugs themselves do not affect vaccination, it is necessary to clarify the reason why the patient is taking anti-inflammatory drugs, because generally patients take anti-inflammatory drugs because their bodies are suffering from infectious diseases, and if they belong to the acute infection period, most vaccines cannot be administered, and vaccination may aggravate the manifestation of inflammation and increase the burden on their own immune systems, and may also have an effect on the effectiveness of the vaccine. Since the patient’s immunity is low during the acute phase of inflammation, vaccination in this case may also produce other adverse reactions.