Headache after vaccination may be an adverse reaction to the vaccine. Vaccines are a foreign stimulus to the human body and may cause adverse reactions after vaccination, such as headache, fever, malaise and other symptoms, which can usually be relieved on their own within a few days after vaccination. Headache after vaccination may also be caused by nervousness, fatigue, or staying up late after vaccination, and may be relieved by rest and relaxation. If the headache lasts longer or is accompanied by continuous fever, cough, vomiting and other symptoms, it may be caused by a cold or hypertensive attack after vaccination, and in a few cases, the possibility of cerebrovascular disease cannot be ruled out, at which time it is recommended that the patient seek medical consultation in a timely manner to clarify the cause and then carry out targeted treatment. If it is caused by a cold, taking ibuprofen and acetaminophen is sufficient. If it is hypertension, you need to take antihypertensive drugs. If it is caused by cerebrovascular disease, medication and surgery are required. After vaccination, it is recommended to ensure a light diet with light and easily digestible food such as porridge and noodle soup, avoid cold and irritating food, and ensure sufficient rest. Patients with headache can have appropriate head massage and ice packs, and those with severe symptoms can take ibuprofen for pain relief, and those whose symptoms cannot be relieved need to go to the hospital for detailed examination and treatment to clarify the cause.